Ronin - Frank Miller
The art seems alien, which fits the themes and the subjects of the work, the title character is an oddity, and you're left wondering, at the end of it all, who really played what role in the course of it all. The characters are dynamic and unique, so much so that you are at a serious loss for what you believe is going to happen next, due to what you think you know about the characters,

What is really going on? I guarantee that you'll be at a serious loss for what it was that just happened, and you won't be disappointed. And confused. But in a good way!